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This item is sold brand new. It is ordered on demand from our supplier and is usually dispatched within 8 - 15 working days Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology explores statistics used in day-to-day clinical pharmacology work. The book covers the methods needed to design, analyze, and interpret bioequivalence trials; explores when, how, and why these studies are performed as part of drug development; and demonstrates the proposed methods using real world examples. Drawing on knowledge gained directly from working in the pharmaceutical industry, the authors set the stage by describing the general role of statistics. Once the foundation of clinical pharmacology drug development, regulatory applications, and the design and analysis of bioequivalence trials are established, they move on to related topics in clinical pharmacology involving the use of cross-over designs. These include, but are not limited to, safety studies in Phase I, dose-response trials, drug interaction trials, food-effect and combination trials, QTc and other pharmacodynamic equivalence trials, and dose-proportionality trials. Purposefully designed to be instantly applicable, the book provides examples of SAS code so that the analysis described can be immediately implemented. The authors have made extensive use of the proc mixed procedures available in SAS. Each chapter includes a vignette based on co-author Scott Patterson's experience in the clinical pharmacology work place and all the data sets are taken from real trials. The authors delineate practical utility and objectives, provide real-world examples of the topic under discussion, and include statistical theory and applications. Technical theory, where extensive, is included in technical appendices at the end of the chapter. Each topic contains worked examples that illustrate the applications of the statistical techniques and their interpretation. The authors also develop statistical tools useful for other topics of clinical pharmacology - namely general safety testing, testing for proarrythmic potential, population pharmacokinetics, and dose-selection. Features Summary Covers the applications and basic elements of the theory of statistical methods in clinical pharmacology. This work establishes techniques used in the assessment of bioequivalence and describes the use of statistics in clinical pharmacology studies of safety... Author Scott D. Patterson (Author), Byron Jones (Author) Publisher Chapman & Hall/CRC Release date 20051110 Pages 400 ISBN 1-58488-530-0 ISBN 13 978-1-58488-530-6

(This title is available on demand: expected date of dispatch will be 4-7 working days once ordered) Ever wondered how perfumes are developed? Or why different scents appeal to different people? The Chemistry of Fragrances 2nd Edition offers answers to these questions, providing a fascinating insight into the perfume industry, from the conception of an idea to the finished product. It discusses the technical, artistic and commercial challenges of the perfume industry in an informative and engaging style, with contributions from leading experts in the field. The book begins with a historical introduction and covers all aspects of the development process - from customer brief to producing a fragrance including; * Ingredients acquisition * Ingredient design and manufacture * Design and analysis of fragrance * Sensory aspects including odour perception * Psychological impact of fragrance * Technical challenges * Safety An updated section on the measurement of fragrance discusses the role of senses in marketing consumer products. This book will appeal to anyone with an interest in the perfumery business and includes an extensive bibliography to enable those interested to explore the field further. It also comes complete with a selection of colour illustrations and a fragranced page. Format:Hardback

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This item is sold brand new. It is ordered on demand from our supplier and is usually dispatched within 7 - 11 working days Inspire, motivate and give confidence to your students with OCR PE for A Level Book 2. This reliable and accessible textbook will offer your students comprehensive support for both the academic and practical elements of the course.We are working in collaboration with OCR to produce the following print resources that support the teaching and learning of the new A Level Physical Education specification- Key questions to direct thinking and help students focus on the key points- Diagrams to aid understanding- Summaries to aid revision and help students access the main points - Extension questions, stimulus material and suggestions for further reading to stretch, challenge and encourage independent thinking and a deeper understanding - Definition of key terms - again to aid and consolidate understanding of technical vocabulary and concepts- Activities to build conceptual understanding and sound knowledge and understanding, analysis, evaluation and application skills Features Summary Inspire, motivate and give confidence to your students with OCR PE for A Level Book 2. This reliable and accessible textbook will offer your students comprehensive support for both the academic and practical elements of the course. Author John Honeybourne (Author), Sarah Powell (Author) Publisher Hodder Education Release date 20160826 Pages 352 ISBN 1-4718-5174-5 ISBN 13 978-1-4718-5174-2

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